The Curious Engineer

All blogs / Science

Rough Diamonds

sarahconstantin.substack.com

Underrated opportunities in science, technology, and society. Click to read Rough Diamonds, by Sarah Constantin, a Substack publication with tens of thousands of subscribers.

ScienceAI / MLSociety / politics / economy

’19’20’21’22’23’24’25’26
Posts
151 from 23 Jan 2019 to 7 Oct 2026
Posting
monthly (15 in the last year)
Kind
personal blog
Feed
https://sarahconstantin.substack.com/feed

2026 12

  1. SS27 Color Stats
  2. AI Companies Are Not (Necessarily) Liable for Unintended AI Cyberattacks
  3. Science and News Twitter/X Summarizer
  4. Some Ways I Think About Evaluating Grant Applications
  5. Don't Dither
  6. Big-World Intuitions
  7. FW26 Color Stats
  8. Things that Go Boom
  9. Getting Back To It
  10. Biotech Startup Stats
  11. Cancer-Selective, Pan-Essential Targets from DepMap
  12. Self-Help Tactics That Are Working For Me

2025 20

  1. Measuring Drug Target Success
  2. Making Sense of Consciousness Part 8: Summing Up
  3. Making Sense of Consciousness Part 7: Volition
  4. SS26 Color Stats
  5. Making Sense of Consciousness Part 6: Perceptions of Disembodiment
  6. Making Sense of Consciousness Part 5: Consciousness and the Self
  7. I Vibecoded a Dispute Resolution App
  8. Making Sense of Consciousness Part 4: States of Consciousness
  9. Making Sense of Consciousness Part 3: The Pulvinar Nucleus
  10. Making Sense of Consciousness Part 2: Attention
  11. Making Sense of Consciousness Part 1: Perceptual Awareness
  12. Tech for Thinking
  13. Broad-Spectrum Cancer Treatments
  14. Who's Working On It? AI-Controlled Experiments
  15. The Uses of Complacency
  16. Prodromes and Biomarkers in Chronic Disease
  17. FW25 Color Stats
  18. AI "Deep Research" Tools Reviewed
  19. Book Review: Affective Neuroscience
  20. What's Behind the SynBio Bust?

2024 36

  1. What Goes Without Saying
  2. The Dream Machine
  3. Neutrality
  4. Bigger Livers?
  5. Join my new subscriber chat
  6. Metastatic Cancer Treatment Since 2010: The Success Stories
  7. Thinking in 2D
  8. 2025 Color Trends
  9. Marine Carbon Dioxide Removal
  10. Fun With The Tabula Muris (Senis)
  11. The Great Data Integration Schlep
  12. Fun With CellxGene
  13. AI for Bio: State Of The Field
  14. LLM Applications I Want To See
  15. All The Latest Human tFUS Studies
  16. Multiplex Gene Editing: Where Are We Now?
  17. Superbabies: Putting The Pieces Together
  18. The Incredible Fentanyl-Detecting Machine
  19. Fine-Tuning LLMs For Style Transfer
  20. Rethinking AI
  21. Status Update: In Progress
  22. Normativity and Anti-Normativity
  23. Bad News for Minicircle
  24. Minicircle Follistatin Gene Therapy: How Legit Is It?
  25. What Really Happens When A Neuron Fires? (Part 2)
  26. Contribution
  27. What Really Happens When A Neuron Fires? (Part 1)
  28. Going Solo
  29. FW24 Color Stats
  30. How I Write
  31. OPM-MEG: A Wearable Window Into Brain Activity?
  32. EEGs: What Can They Do?
  33. Emotion Regulation Regions, Part 2
  34. Neural Correlates of Emotional Resilience
  35. Noninvasive Brain Activity Imaging
  36. Color Stats with GPT-4

2023 25

  1. What does the Cerebellum Do Anyway?
  2. 2024 Color Trends
  3. Risks of Ultrasound Neuromodulation
  4. Testing Human Augmentation
  5. Who's Working on Ultrasound Neuromodulation?
  6. Why Should Neuroenhancement Be Possible?
  7. Transcranial Ultrasound Studies, Part 2
  8. Transcranial Ultrasound Neuromodulation: The Studies
  9. How Ultrasound Neuromodulation Works
  10. Ultrasound Neuromodulation
  11. The Enchippening of Medical Imaging
  12. The World of MEMS
  13. The Enchippening
  14. Technology Alignment Political Compass
  15. Goals (and Not Having Them)
  16. Sarcopenia Experimental Treatments
  17. "Scaling Laws" for AI And Some Implications
  18. Why I am Not An AI Doomer
  19. 600+ Early-Stage Projects
  20. Motivation, Volition, Control
  21. Attestation
  22. It's All About The Fnords
  23. The Health Risks of Gas Stoves
  24. Don't Get Even, Get Mad
  25. What "Matters"?

2022 35

  1. Hedonism Revisited
  2. Science Court
  3. Why Infinite Coin-Flipping is Bad
  4. Non-State Courts
  5. The Need for Canonicity
  6. Bad Ideas Can Get Surprisingly Far
  7. Unblocking Abundance 2: Organizations
  8. Unblocking Abundance
  9. Benevolence and Malevolence, Conflict and Mistake
  10. Things that Increase Female Reproductive Lifespan
  11. "Primal" Worldviews
  12. Tradeoffs are not Opposites
  13. Benevolence and Malevolence
  14. "Metta" Meditation, My Way
  15. Experiment: Pay for "Squishy" Content
  16. Is Human Intelligence Simple? Part 4: Searching for Animal IQ
  17. Is Human Intelligence Simple? Part 3: Disambiguating Types of Simplicity
  18. Is Human Intelligence Simple? Part 2: Genetics
  19. Is Human Intelligence Simple? Part 1: Evolution and Archaeology
  20. Is Human Intelligence Simple? Part 0: Intro
  21. Fine. Monkeypox.
  22. Grid Scale Energy Storage Deployment By Technology Type: Part 2
  23. Grid Scale Energy Storage Deployment by Technology Type: Part 1
  24. Not Enough Energy Storage
  25. In Search of Opportunity
  26. Molten-Salt Batteries
  27. Zinc-Air and Iron-Air Batteries
  28. Beyond Lithium-Ion: New Battery Chemistries
  29. Are We Running Out of Lithium?
  30. Predicting Growth in the Battery Industry
  31. Progesterone for Postpartum Depression
  32. Wearable Hormone Sensors
  33. Is Buzz Good For Business?
  34. Paid Subscriptions Now Available
  35. Industrializing Mammalian Cell Culture

2021 9

  1. Old Spleens Suck
  2. Non-Invasive Deep Brain Stimulation
  3. Rough Diamonds: Underrated Opportunities in Science, Technology, and Society
  4. Interesting rTMS Results in Healthy People
  5. Are Cancer Cells More Negatively Charged?
  6. How To Be An Educated Layman
  7. Do High-Performing Investment Firms Drive Out Low Performers?
  8. Does It Pay To Do More Research?
  9. Mammalian Aggression

2020 4

  1. Chronic Mania and Persistent Euphoric States
  2. COVID-19 Vaccine Update
  3. Moving to New York
  4. Dose-Response Effects of Viral Exposure in COVID-19

2019 10

  1. Asking Permission
  2. The Costs of Reliability
  3. Book Review: Why Are The Prices So Damn High?
  4. Circle Games
  5. Pecking Order and Flight Leadership
  6. Degrees of Freedom
  7. Personalized Medicine For Real
  8. The Tale of Alice Almost: Strategies for Dealing With Pretty Good People
  9. Humans Who Are Not Concentrating Are Not General Intelligences
  10. The Relationship Between Hierarchy and Wealth