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Trevor Klee’s Newsletter

trevorklee.substack.com

Long, niche posts, mostly about biology. Click to read Trevor Klee’s Newsletter, a Substack publication with thousands of subscribers.

ScienceEssays / personal

’22’23’24’25’26
Posts
159 from 7 Jan 2022 to 18 Sep 2026
Posting
monthly (21 in the last year)
Kind
personal blog
Feed
https://trevorklee.substack.com/feed

2026 14

  1. Sulfate cooling the Earth is cheap, doable, and coming soon
  2. Looking for London
  3. When you can no longer see the banana tree
  4. The dreadful burden of reading the methods
  5. Writing a blog post at the end of the world
  6. Non-responsive is non-responsive
  7. Maybe having kids has always sucked
  8. Sign-up for NeutraOat pre-orders below!
  9. We've turned PFAS from forever chemicals into couple month chemicals.
  10. Writing about Boston from the old Congregational Library
  11. I've never loved dishwashing
  12. I love America.
  13. Thoughts on A Brief History of Intelligence
  14. Brief impressions of Las Vegas and San Diego

2025 42

  1. The trouble with remission
  2. Borges's world of words
  3. Puzzling out elephant longevity
  4. Those who danced were thought insane by those who couldn't hear the music
  5. My dad's obituary
  6. Dreams of the dying
  7. Kant in the age of AI
  8. Extending the analogy of the body as a factory
  9. A late September Tuesday in Vienna
  10. Zen, motorcycles, artists, engineers, and scientists
  11. The dangers of pseudoscience
  12. Thoughts on my stay in the Tenderloin
  13. The glorious Soviet Union
  14. Can fiber remove PFAS?
  15. The place of machines in children's society
  16. WeWork and the temporary end of history
  17. We need to industrialize virtual synthetic repurposing trials
  18. The place of humans in machine society
  19. Call of Duty as a lens into American foreign policy from 2003-2025
  20. How to get rich combining generic drugs: lessons from Axsome
  21. The chemical reason that PFAS are "forever chemicals"
  22. E is for Engaged
  23. 32nd Birthday Thoughts of Waterworld
  24. Critique my new website, please!
  25. 10 years out from Princeton and headed back
  26. Another entry for the repurposing files
  27. San Francisco meetup this Saturday afternoon!
  28. The evidence on plasticizer health harms
  29. I will be in San Francisco from May 2-5
  30. What if the declines of aging are just the declines of taurine?
  31. Do taurine and glycine provide answers to the mammalian gallbladder and kidney mysteries?
  32. Plainclothes ICE officers threaten the trust needed for the police to function
  33. Did Harvard need to do a hiring freeze?
  34. Microplastics, your body, and you: a primer
  35. The performative cruelty of it
  36. What do you think of my solution for the microplastics issue?
  37. Some ants can choose to live 5x as long
  38. A Search for Sick Animals
  39. On the responsibility of size
  40. Why am I bad at Scrabble?
  41. Regulators almost killed biotech before it began
  42. A brief analysis of the PlasticList report

2024 36

  1. Reflections on a brief visit to Florida
  2. Thinking about a cure for pain, again
  3. The Manhattan Project through the eyes of Fermi
  4. Cracking biological emergence with mechanistic interpretability
  5. If langurs can drink seawater, can humans do so as well?
  6. No human genes have truly 100% penetrance
  7. Are drugs good? Are side effects bad? It depends on what you're trying to do.
  8. A brief personal history of optimistic futures
  9. My guide to the November 2024 Massachusetts State Election
  10. Lessons on getting things done from Robert Moses
  11. A list of health problems that should be solved pet-first
  12. Culturing honesty
  13. My friend, Claude
  14. Thoughts on California from a brief visit
  15. Forget it, Jake, it's synbio town.
  16. Animal health is still in its infancy
  17. A short rundown of how animal drugs are regulated
  18. Is lactate as important as glucose for metabolism?
  19. How do waterdwelling turtles survive the winter?
  20. Why humans keep getting viruses from bats
  21. Birthday dreams
  22. I'm in the San Francisco Bay Area from Thursday to Sunday!
  23. On the safety of microplastics
  24. My about-face on Lumina
  25. Updates on Lumina Probiotic
  26. Please don't take Lumina's anticavity probiotic
  27. Is longevity a choice? How about obesity?
  28. The way scientists think about obesity now is wrong.
  29. GLP-1 and GIP agonism and antagonism is weird
  30. The twin mysteries of GLP-1 receptor agonists
  31. Viking Therapeutics has an $8 billion market cap with 27 full time employees. This is their story.
  32. When your family becomes inverse strangers
  33. Karuna Therapeutics, a drug repurposing effort, sold for about $14 billion. This is their story.
  34. 5 Whys of Diabetes
  35. How to get causation from correlation in genetics
  36. Let's be more sincere in the New Year

2023 37

  1. Ground squirrel microbiomes are neat, unlike human microbiomes
  2. I have no gift for gift-giving
  3. I'll be in the Bay area from December 5-7 for the Buck Longevity Conference. Wanna meet up?
  4. My life through Halo
  5. Anthropocentrism, insulin, and obese, long-lived cavefish
  6. On the preciousness of life
  7. Why don't hummingbirds get diabetes? A glycolytic mystery.
  8. Pharmacokinetics: drug development's broken stair
  9. I'm in SF/Berkeley this weekend for Manifest 2023!
  10. A geosciences paper is fraudulent? I'm not surprised.
  11. The Tao of Fetch
  12. Back then, I never thought it'd be a long time ago
  13. When rational drug design meets an irrational disease
  14. Is this all the medicine we were promised?
  15. Why do we try to redeem criminals by looking at their upbringing?
  16. Looking for your keys under the light
  17. How to apply for MassHealth: an 18 step guide
  18. Bloody Mary was not exceptionally bloody
  19. Does herpes cause dementia?
  20. Something interesting is happening in Tulsa
  21. We have changed the language game we play with computers
  22. Should ethical philosophers be ethical themselves?
  23. You live in a world that philosophy built
  24. A miracle drug sold over the counter
  25. Can an AI ever be as intelligent as a bat?
  26. Part of why ChatGPT's writing ability surprises
  27. Definitions have consequences
  28. My advice about going to graduate school to change your career
  29. The curse of having too much money in biotech
  30. Should you work for Neuralink? Probably not.
  31. Letter to a young biotech founder
  32. How to manufacture a drug
  33. I passed Step 1 of the FDA's flowchart!
  34. Bacterial vaginosis: we contain multitudes
  35. Diagnosing and treating chronic cough
  36. An update on my struggle with step 1 of the FDA's 15 step flowchart
  37. What to do when the tide is going out

2022 30

  1. My struggle with step 1 of the FDA's 15 step flowchart
  2. Peculiar facets of my ordinary, middle-class American childhood
  3. The place of AI/ChatGPT in drug discovery
  4. Prilosec, Nexium, and the narrowing of pharmaceutical ambition
  5. Things I've noticed while visiting the ICU
  6. The AGI prediction community needs an IPCC report
  7. Artificial General Intelligence (AGI) timelines ignore the social factor at their peril
  8. Drug trials have a surprising amount of detail
  9. I appeared on the Narratives podcast to discuss drug development!
  10. The FTX Future Fund needs to slow its charitable spending way down
  11. Steelmanning chiropractic
  12. How I've tried to fix my lower back pain
  13. What do you think of our new crowdinvesting pitch?
  14. How much my cat drug has cost
  15. Is it possible to explicitly teach intuition in the sciences?
  16. Biology has analogies, not paradigms
  17. Effective criticism
  18. Why does the flu/COVID make us tired?
  19. Are being big and old risk factors for cancer or not?
  20. Vets today are like doctors yesterday
  21. Why I'm now making drugs for cats (and you should, too)
  22. How to win an election in 10 easy steps: an effective altruist's guide
  23. Obesity's relationship with type 2 diabetes is really weird
  24. A medical thought experiment
  25. One neat trick for instantly improving medical trials (scientists hate this!)
  26. Can gene therapy fix any genetic defect?
  27. The manifold effects of tetracycline
  28. The Epstein-Barr virus causes multiple sclerosis. So what?
  29. My terrible plan for reducing opioid-related deaths
  30. Coming soon