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The Curious Wavefunction

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Musings on science, history, philosophy and literature

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1,123 from 15 Dec 2004 to 17 Jun 2025
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2025 4

  1. Richard L. Garwin (1928-2025): Force of Nature
  2. Preventing misuse of chemistry cloud labs by bad actors
  3. Minority Report Meets Drug Discovery: Intelligent Gestural Interfaces and the Future of Medicine
  4. Why Technology (and AI) Won’t Save Biology

2024 11

  1. Books read in 2024
  2. Review: "Letters", by Oliver Sacks
  3. From Valley Forge to the Lab: Parallels between Washington's Maneuvers and Drug Development
  4. Timeless Figures, #2: Werner Heisenberg
  5. Timeless Figures, #1: Albert Einstein
  6. Areopagitica and the problem of regulating AI
  7. Daniel Dennett (1942-2024)
  8. Simple, atypical but neat estimation of energy released in fission
  9. Book Review: "Into Siberia: George Kennan's Epic Journey Through the Brutal, Frozen Heart of Russia", by Gregory Wallance
  10. Jack Dunitz (1923-2021): Chemist And Writer Extraordinaire
  11. How Niels Bohr predicted Rydberg atoms

2023 7

  1. Galton's "Hereditary Genius" (1871)
  2. John Polkinghorne's "Belief in God in an Age of Science"
  3. Tolman, “The Principles of Statistical Mechanics, Chapter 1, Part 1
  4. 100 Desert Island Books
  5. Brenner, von Neumann and Schrödinger
  6. On change
  7. Book Review: Chip War: The Fight for the World's Most Critical Technology

2022 16

  1. A Science Thanksgiving
  2. Book review: A Divine Language: Learning Algebra, Geometry, and Calculus at the Edge of Old Age, by Alec Wilkinson
  3. Temple Grandin vs algebra
  4. David McCullough (1933-2022)
  5. Book review: "The Apocalypse Factory: Plutonium and the Making of the Atomic Age", by Steve Olson
  6. The root of diverse evil
  7. Book review: "Unraveling the Double Helix: The Lost Heroes of DNA", by Gareth Williams.
  8. Brian Greene and John Preskill on Steven Weinberg
  9. A long time ago, in a galaxy far, far away
  10. Book Review: "The Rise and Reign of the Mammals: A New History, From the Shadows of the Dinosaurs to US", by Steve Brusatte
  11. Book Review: "Don't Tell Me I Can't: An Ambitious Homeschooler's Journey", by Cole Summers (Kevin Cooper)
  12. Should a scientist have "faith"?
  13. Man as a "machine-tickling aphid"
  14. Philip Morrison on challenges with AI
  15. Consciousness and the Physical World, edited by V. S. Ramachandran and Brian Josephson
  16. Rutherford on tools and theories (and machine learning)

2021 13

  1. Has Carl Sagan's "Contact" aged well?
  2. When it comes to science, the practical is the moral and the moral the practical
  3. Complementarity And The World: Niels Bohr’s Message In A Bottle
  4. Steven Weinberg (1933-2021)
  5. Kurt Gödel's open world
  6. Jim Simons: "We never override the computer"
  7. Review: James Hornfischer's "The Fleet at Flood Tide".
  8. Malcolm Gladwell's "The Bomber Mafia" - Weak Tea
  9. The human problems with molecular modeling
  10. Book review: Charles Seife’s “Hawking Hawking”
  11. Chandra and Johnny come close to discovering black holes
  12. "Hawking Hawking" and Michio Kaku
  13. Six lessons from the biotech startup world

2020 18

  1. Some thoughts on "broader impact" statements for scientific papers
  2. Book Review: "His Very Best: Jimmy Carter, A Life" by Jonathan Alter
  3. Book Review: "The Jews of Spain", by Jane Gerber
  4. Book Review: "The Pity Of It All: A Protrait of the German-Jewish Epoch", 1743-1933, by Amos Elon
  5. Book Review: "Against the Grain", by James Scott
  6. Two views of America
  7. A Foray into Jewish History and Judaism
  8. Life. Distributed.
  9. Brains, Computation And Thermodynamics: A View From The Future?
  10. On free speech, crossing the Rubicon and the need to unite
  11. Von Neumann In 1955 And 2020: Musings Of A Cheerful Pessimist On Technological Survival
  12. Book Review: "American Rebels", by Nina Sankovitch
  13. Book review: Quantum mechanics and quantum mechanics. David Kaiser's "Quantum Legacies: Dispatches from an Uncertain World"
  14. What John von Neumann really did for modern computing
  15. The last great contrarian?
  16. Freeman Dyson (1923-2020): A personal remembrance
  17. The case for dumb kindness
  18. The Fermi-Pasta-Ulam-Tsingou Problem: A Foray Into The Beautifully Simple And The Simply Beautiful

2019 19

  1. Book review: "Edison", by Edmund Morris
  2. Book review: “Lithium: A Doctor, a Drug, and a Breakthrough” by Walter Brown
  3. Spooky factions at a distance
  4. A new paper on kinase inhibitor discovery: not one on "drugs", and not one on an "AI breakthrough"
  5. Mathematics, And The Excellence Of The Life It Brings
  6. The three horsemen of the machine learning apocalypse
  7. Infinite horizons; or why I am optimistic about the future
  8. Book review: The British Are Coming: The War for America, Lexington to Princeton, 1775-1777
  9. Life And Death In New Jersey
  10. Book review: The Ideological Origins of the American Revolution by Bernard Bailyn
  11. Book review: The Island at the Center of the World: The Epic Story of Dutch Manhattan and the Forgotten Colony That Shaped America
  12. Book review: An Empire on the Edge: How Britain Came to Fight America
  13. Computer simulations and the Universe
  14. Book review: Roger Williams and the Creation of the American Soul
  15. Book review: Fur, Fortune and Empire
  16. Book review: Miracle at Philadelphia
  17. Chemistry is not harder than other sciences...just different.
  18. Open Borders
  19. Modular complexity, and reverse engineering the brain

2018 28

  1. This year's 100 book odyssey
  2. Will CADD ever become relevant to drug discovery?
  3. Late hour
  4. What areas of chemistry could AI impact the most? An opinion poll
  5. Can we turn biology into engineering?
  6. Victor Weisskopf and the many joys of scientific insight
  7. 30 favorite books
  8. A potentially revolutionary new technique for chemical structure determination
  9. Lessons from Tom Steitz, surveyor of molecular empires (1940-2018)
  10. Big discoveries from little things
  11. On Nobel Prizes, Diversity And Tool-Driven Scientific Revolutions
  12. A meeting with V. S. Naipaul
  13. Technological convergence in drug discovery and other endeavors
  14. If you want to improve AI, let it evolve toward emergence
  15. On their birthday: The wisdom of John Wheeler and Oliver Sacks.
  16. Science and faith in a ceremonial cave
  17. JFK, nuclear weapons and the 1963 'Peace Speech': Looking back sixty five years
  18. The birth of a new theory: Richard Feynman and his adversaries
  19. Secrets of the Old One
  20. Dreams of a technocrat: Review of William Perry's "My Journey at the Nuclear Brink"
  21. Bridging the gaps: Einstein on education
  22. Who's the greatest physicist in American history?
  23. Why the world needs more Leo Szilards
  24. The Ten Commandments of Molecular (and other) Modeling
  25. The only two equations that you should know
  26. Book review: "John von Neumann" by Norman Macrae
  27. My favorite popular math books
  28. Is our emphasis on lab safety keeping us from doing important science?

2017 52

  1. Book Review: Jacob Bronowski's "The Origins of Knowledge and Imagination"
  2. Is Big Data shackling mankind's sense of creative wonder?
  3. Staying after the party is over: Nobel Prizes and second acts
  4. A book burning in Palo Alto
  5. A terrible year for academic organic chemistry
  6. Interpreting Kafka’s Metamorphosis in the Digital Age
  7. Einstein: A Hundred Years of Relativity
  8. Fine-tuning the future: A review of Aldous Huxley's "Brave New World"
  9. Cryo-electron microscopy, scientific convergence and - again - why we need to fund basic science
  10. The Madness of J. Robert Oppenheimer: A poem
  11. Domains of Applicability (DOA) in top-down and bottom-up drug discovery
  12. 2017 Nobel Prize picks
  13. Heisenberg on Helgoland
  14. Carl Sagan's 1995 prediction of our technocratic dystopia
  15. How to thrive as a fox in a world full of hedgehogs
  16. The bomb ended World War 2: And other myths about nuclear weapons
  17. A Manhattan Project for AI?
  18. Want to know if you are depressed? Don't ask Siri just yet.
  19. Cognitive biases in drug discovery, part 2: Anchoring, availability and representativeness
  20. Black holes and the curse of beauty: When revolutionary physicists turn conservative
  21. Friday Book Review: "The One Device: The Secret History of the iPhone"
  22. Lab automation using machine learning? Hold on to your pipettes for now.
  23. Silvan "Sam" Schweber (1928-2017)
  24. Cognitive biases in drug discovery: Part 1
  25. Bottom-up and top-down in drug discovery
  26. Unifiers and diversifiers in physics, chemistry and biology
  27. If you believe Western Civilization is oppressive, you will ensure it is oppressive
  28. Why the world needs more Leo Szilards
  29. October, 1949: Oppenheimer is on the cover of LIFE, and cigarettes are still cool
  30. On John F. Kennedy's 100th birthday: Let us begin
  31. On the primacy of doubt in an age of illusory certainty
  32. Brave New World: A review of Jennifer Doudna and Samuel Sternberg's "A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution"
  33. Jesuits, science, and a pope with a chemistry background
  34. Kurt Gödel's Open World
  35. Science books for 14-year-olds
  36. Sixty-four years later: How Watson and Crick did it
  37. R. B. Woodward, general problems and the importance of timely birth
  38. Intramolecular Hydrogen Bonds, We Hardly Knew Thee
  39. Richard Feynman's sister Joan's advice to him: "Imagine you're a student again"
  40. On the absurdity of classified information
  41. Why technology won't save biology
  42. On Albert Einstein's birthday: How Eddington and Einstein set an example for the international fellowship of science
  43. Yuval Noah Harari's "Homo Deus": Sweeping, clever and provocative, but speculative and incomplete
  44. Macrocycles, flexibility and biological activity: A tortuous pairing
  45. An open letter to my fellow industry scientists: Why the March for Science must be led by us
  46. Darwin Day: A personal offering
  47. Why the world needs more Leo Szilards
  48. Born on this day: Physicist Emilio Segrè, who changed the direction of the Manhattan Project
  49. Irving Langmuir and pathological science: A warning for our times
  50. Einstein's wonderful letter to David Hilbert: A message for our times
  51. Gertrude Elion: Nobel Laureate, inventor of lifesaving drugs, woman in science
  52. Physics Nobel Prize winners and second acts: A rare pairing

2016 87

  1. Infinite in All Directions: Freeman Dyson at 93
  2. Drones, Silicon Valley and biology: The future isn't here yet
  3. Leroy Hood and the tool-driven revolution in biology
  4. Oppenheimer's folly: On black holes, fundamental laws and pure and applied science
  5. Seeing the 2016 election through Jonathan Haidt's moral foundations theory
  6. Richard Feynman on our difficult times: "Whatever else is going on, we've always got our physics."
  7. BAGIM event on computational chemistry careers
  8. Lise Meitner's 48 Nobel Prize nominations
  9. Jack Roberts and Dorothy Semenow - Caltech's first female graduate student
  10. Steve Jobs on what happens to companies when sales people take over product people
  11. A really bad year for chemistry and chemists
  12. How chemistry exemplifies the Fermi method
  13. The man with an inside track to God: A new biography of Enrico Fermi
  14. Subrahmanyan Chandrasekhar: A study in fortitude and rigor
  15. Psychiatry and neuroscience: Don't sacrifice proven emergence at the altar of unproven reductionism
  16. Black clouds and silver linings: 2016 chemistry Nobel Laureate Fraser Stoddart's moving tribute to his wife
  17. Iconic images of science, #1: Rosalind Franklin's DNA photograph
  18. Big Trouble in Little Synthetic Organic Chemistry?
  19. Physics and the search for fundamental laws: Is physics turning into biology?
  20. 2016 Nobel Prize picks
  21. Why drug discovery is hard, part 2: On the unpredictable and complicated origins of drug species
  22. Let's embrace this new era of private science funding
  23. Why drugs are expensive: Follow the science (and not just the money)
  24. What is chemical intuition?
  25. The same and not the same: Carboxylic acids and tetrazoles
  26. Roger Tsien (1952-2016): Tool builder extraordinaire
  27. Ernest Rutherford: Master of simplicity, mentor without peer
  28. A bond by any other name...: How the simple definition of a hydrogen bond gives us a glimpse into the heart of chemistry
  29. Those who cannot predict...discover?: On 'deliberate serendipity' in drug design
  30. The rise of translational research and the death of organic synthesis (again)?
  31. Conquering the curse of morphine, one docked structure at a time
  32. Physicist Ed Witten on consciousness: "I tend to believe that it will remain a mystery"
  33. Physics, biology and models: A view from 1993 and now
  34. Portrait of the human as a tangled bank: A review of "I Contain Multitudes: The Microbes Within Us and a Grander View of Life"
  35. Protein-protein interactions: Can't live without 'em, can't easily drug 'em
  36. DNA-encoded libraries: Bring me the drugs
  37. What Oliver Sacks could teach us about the value of anecdotal information in drug discovery research
  38. The Billion-Dollar Heartbreak
  39. Big things come in little packages: How Willis Lamb's tiny measurement revolutionized 20th century physics
  40. The linguistic adventures of Robert Burns Woodward
  41. On Patrick Blackett, the ideal experimental physicist, and what it takes to excel at interdisciplinary research
  42. Lessons on management styles from Edward Teller, Hans Bethe and Robert Oppenheimer: A question of temperament
  43. So, what exactly do you do for Evil McSinister Corporation?
  44. Two politicians speak out against the Air Force's new cruise missile
  45. Unifiers and diversifiers in chemistry and other sciences
  46. "Understand what I love about America": Physicist Hans Bethe's moving letter to his teacher Arnold Sommerfeld
  47. Mendel, Weldon and the uncertainty of counterfactuals
  48. Friday levity: Darwin Myths
  49. Skeptics should cast a much wider net
  50. The future - not in our stars but in our genes: A review of Siddhartha Mukherjee's "The Gene: An Intimate History"
  51. Cancer and the origins of life: The Age of Metabolism
  52. Reality is a many-splendored thing: A review of Sean Carroll's "The Big Picture"
  53. Watch "The Man Who Knew Infinity": You will be performing a public service
  54. Harry Kroto (1939-2016): A salesman of science in the best sense of the term
  55. James P. Snyder (1939-2016)
  56. Kuhn, Galison and Dyson: Tool-driven and idea-driven revolutions in chemistry and biology
  57. On AlphaGo, chemical synthesis and the rise of the intuition machines
  58. What makes me human? On personhood and levels of emergence
  59. Nimbus Therapeutics and computational drug discovery: A promising start with much data to plumb
  60. NSA, data uncertainty, and the problem of separating bad ideas from good ones
  61. W B Yeats's "A Poet to his Beloved": Molecular modeling version
  62. The only science equation that you should know
  63. Nobelist Roger Kornberg: "If there is any one subject an educated person should know, that is chemistry"
  64. Oliver Sacks's "mad and impudent" idea for winning first prize in an important exam: five pints of hard cider
  65. Lessons on scientific leadership: From Medawar, Perutz, Oppenheimer and others
  66. R B Woodward. Vitamin B12. 3.5 hours. Enough said.
  67. Darwin's "endless forms most beautiful" quote...applied to chemistry
  68. Hit picking parties, eviscerating weaknesses and other vistas from the world of molecular docking
  69. Why healthcare might not have benefited from a Steve Jobs-style disruptor
  70. Here's that prospective drug design study you asked for...
  71. Carlo Rovelli's "Seven Brief Lessons on Physics": A beautiful and poignant meditation on the laws of physics and our place in the cosmos
  72. On gravitational waves and the virtue of patience
  73. When Einstein was wrong: Black holes
  74. Gravitational waves, the man behind them, and two of the deepest puzzles confronting humanity
  75. Darwin and his vision of life: A personal offering
  76. The discovery of gravitational waves is the perfect opportunity for the Nobel Prize committee to change its rules
  77. Why the world needs more Leo Szilards
  78. Does the discovery of gravitational waves foretell the "end of physics"?
  79. Billionaires and science prizes: "Fund the science, not the prizes"
  80. What math can teach us about drug discovery and biology (and all of science, really)
  81. The virtualization of drug discovery is not the actualization of drug discovery
  82. What do we need? A Jarvis for molecular modeling. When do we need him? Yesterday.
  83. Book review: Andrea Wulf's "The Invention of Nature: Alexander von Humboldt's New World"
  84. George Whitesides: "Chemists - we change the way you live or die"
  85. Book review: Simon Winchester's "Pacific" - A "behemoth of eye-watering complexity"
  86. The Djabugay medicine woman and the varieties of knowledge
  87. Hypotheses non fingo: Why chemistry defies the traditional philosophy of science

2015 93

  1. A Christmas message from Steve Jobs for our friends in pharma: 2015 version
  2. The AAAS's nomination of Prof. Patrick Harran does a grave disservice to their stated mission
  3. Abraham Flexner, the Institute for Advanced Study, and the usefulness of useless knowledge
  4. Environmentalism is not climate change; climate change is not environmentalism
  5. The late Paul Kalanithi's book "When Breath Becomes Air" is devastating, edifying, eloquent and very real
  6. Science as a messy human endeavor: The origin of the Woodward-Hoffmann rules
  7. Einstein, Oppenheimer, relativity and black holes: The curse of fundamentalitis
  8. The death of new reactions in medicinal chemistry?
  9. The death of medicinal chemistry?
  10. Beware of von Neumann's elephants using bulldozers to model quarks
  11. Linus Pauling's last laugh? Vitamin C might be bad news for mutant colorectal cancer
  12. Physicist Leo Kadanoff on reductionism and models: "Don't model bulldozers with quarks."
  13. (Ir)rational drug design and the history of 20th century science
  14. "The Hunt for Vulcan": Theory, experiment, and the origin of scientific revolutions
  15. When Skynet finally gets here it will be analog, not digital
  16. The 2015 Medicine Nobel Prize is a tribute to drug discovery, chemistry and traditional medicine
  17. George Whitesides to chemists: Move away from the molecule
  18. Identical ligands, unrelated proteins, similar energies - When language collides with the facts of nature
  19. 2015 Nobel Prize predictions
  20. 3 Quarks Daily annual science writing prize
  21. Agonists and antagonists, and why drug discovery is hard (again)
  22. Prof. Erland Stevens's edX med chem class
  23. The 111 Nobel Prize nominations of Robert Burns Woodward
  24. Peter Thiel on biotechnology again: "Get rid of the randomness"
  25. Cryo-electron microscopy: A prime example of a tool-driven scientific revolution
  26. Why foxes are more important than hedgehogs in drug discovery
  27. On live-tweeting at conferences
  28. What would be a "non-intuitive" prediction in medicinal chemistry?
  29. Robert Oppenheimer, Hans Bethe and the value of balance and compromise
  30. The enduring legacy of Leo Szilard, father of the atomic age
  31. Once again, the problem is not synthesis, it's design
  32. The problem with molecular modeling is not just molecular modeling
  33. On the impact of social media and Twitter on scientific peer review
  34. The Tim Hunt affair is destroying our community from within. We need to not let that happen.
  35. Bethe's Dictum: "Always work on problems for which you possess an unfair advantage"
  36. Book review: Leonard Mlodinow's "The Upright Thinkers:The Human Journey from Living in Trees to Understanding the Cosmos"
  37. John Keats's "Chapman's Homer" (chemistry and drug discovery version)
  38. The fundamental philosophical dilemma of chemistry
  39. Want to bind small molecules? Get a backbone
  40. We are all Hamiltonians. We are all Newtonians.
  41. Dynamic monopolies and the laws of thermodynamics: An interesting correspondence
  42. How Linus Pauling almost gave Matt Meselson tellurium breath
  43. Feynman to Wolfram: "You have to extract yourself from the organization in order to run it"
  44. A recommendation letter to die for
  45. John Nash's nighttime chalkboard scribblings
  46. On the ethics of that "chocolate sting" study
  47. John Nash's work makes as good a case as any for the value of curiosity-driven research
  48. Placebos can be really complicated
  49. A review of Freeman Dyson's "Dreams of Earth and Sky"
  50. The difference between popular chemistry and popular physics
  51. Heisenberg and Dirac in the age of NIH funding
  52. We do not need to discard old scientific role models in order to embrace new ones
  53. A review of David McCullough's "The Wright Brothers"
  54. Is mathematics necessary for doing great science?
  55. A review of Marcia Bartusiak's "Black Hole: How an Idea Abandoned by Newtonians, Hated by Einstein, and Gambled On by Hawking Became Loved"
  56. Thermodynamics in drug discovery: A Faustian bargain cooked in a devil's stew?
  57. Peter Thiel's interesting comparison of biotech with software
  58. A review of Philip Schewe's "Maverick Genius", a biography of Freeman Dyson
  59. What is the probability of a chemist discovering a drug? Is that the right question?
  60. Moore's Law turns 50: The End of the Beginning?
  61. Shape vs vibration: Continuous rather than discrete?
  62. Nobelist John Pople on using theories and models the right way
  63. A molecular modeler to his beloved (medicinal chemist)
  64. We need new models of popular physics communication
  65. If computational recipes were like food recipes...
  66. Top 10 popular chemistry books for the general reader
  67. In drug discovery, what counts is asking the right question
  68. "In surprise advance announcement, 2013 Nobel Prize in physics awarded to Higgs boson"
  69. Neuroscience and other theory-poor fields: Tools first, simulation later
  70. Pauling vs Woodward: It's on
  71. Molecules, software and function: Why synthesis is no longer chemistry's outstanding problem.
  72. Memo to chemists: Move away from the molecule
  73. Three reasons why nobody should be surprised by junk DNA
  74. The data junkie and the lamp post: Cancer, genomics and technological solutionism
  75. Physicists in biology, inverse problems and other quirks of the genomic age
  76. Tom Morton-Smith's "Oppenheimer": Slight, trite and unoriginal
  77. How to recognize (and talk to) a chemophobe
  78. Derek Lowe to world: "Beware of von Neumann's elephants"
  79. Why the world needs more Leo Szilards
  80. A canard about Robert Oppenheimer in Louise Gilder's "The Age of Entanglement"
  81. Modular complexity and the problem of reverse engineering the brain
  82. The breadth of Carl Djerassi's scientific work
  83. Pathogen resistance can track with drug penetration, not just with drug number or variety
  84. Carl Djerassi (1923-2015): Chemist, writer, polymath, cultural icon
  85. Precision medicine is not precision engineering
  86. Boundary value conditions, domain applicability and "American Sniper"
  87. Surprises in physics: From black bodies to the accelerating universe
  88. "Clueless machines being ceded authority far beyond their competence"
  89. The many tragedies of Edward Teller
  90. Is this the dawn of a golden age of private science funding?
  91. A good year for science movies
  92. Book Review: Elizabeth Kolbert's "The Sixth Extinction"
  93. Naomi Oreskes and false positives in climate change: Do we know enough?

2014 66

  1. In the matter of Walter Lewin, MIT goes medieval
  2. The demise of SciAmBlogs
  3. The name's bond - reversible covalent bond.
  4. Paul Schleyer: Among the last of the universalists
  5. Philosophy begins where physics ends, and physics begins where philosophy ends
  6. Oppenheimer’s Folly: On black holes, fundamental laws and pure and applied science
  7. Molecular modeling and physics: A tale of two disciplines
  8. Falsification and chemistry: What’s the rub?
  9. Falsification and its discontents
  10. The simple physics behind a horrible tragedy: A tape measure with the energy of a 0.45 Colt bullet
  11. Biologists, chemists, math and computing
  12. Edward Teller plays Beethoven's Moonlight Sonata
  13. The rise of the male nerd and the decline of female computer scientists
  14. The 100 most highly cited papers of all time: Tools, not ideas
  15. Schrodinger and Hawking in the Starbucks line
  16. Frankenstein and his monster in the age of Oprah and NIH funding
  17. Isaiah Berlin, science and the dangers of certainty
  18. Ahmed Zewail and the challenges of intercultural chemistry
  19. On Freeman Dyson, cadmium estimation and the joy of chemistry
  20. David Greenglass and Robert Oppenheimer: A lesson from history
  21. Who's the world's greatest living chemist?
  22. The demise of ScienceOnline
  23. Edward Witten, chemistry and the problems with falsification
  24. The 2014 Nobel Prize in Chemistry and tool-driven scientific revolutions
  25. Updated #chemnobel odds for tomorrow
  26. Maryland Congressman asks the NIH to fund more young scientists
  27. The hidden dangers of HIV
  28. Prof. Erland Stevens's online medicinal chemistry course
  29. It's the most wonderful time of the year...#2014Nobels
  30. What if the Manhattan Project had been like an Alzheimer's disease drug discovery project
  31. Happy Birthday to the man who found life slipping away from his fingers
  32. Happy Birthday to the man with five brains
  33. Modular drug design software?
  34. The 2014 Fields and Nevanlinna prizes: Celebrating diversity
  35. How Robin Williams helped me out in graduate school
  36. Celebrating the 1939 Leo Szilard letter to FDR and setting the record straight
  37. The complex truth about "smart" drugs
  38. Paul Dirac: The Ernest Hemingway of physics
  39. Genius and Einstein: From 'Great Man' to 'Every Man'?
  40. The problem with Food Babe
  41. A response to recent events on Sci Am Blogs
  42. Richard Feynman, sexism and changing perceptions of a scientific icon
  43. Molecular modeling and physics: A tale of two disciplines
  44. Crystallography and chemistry: The culture issue
  45. Phil Baran is a man of style. We, of course, knew that for a while.
  46. Free Energy Perturbation (FEP) methods in drug discovery: Or, Waiting for Godot
  47. The structure of DNA, 61 years later: How they did it.
  48. Drug costs and prices: Here we go again
  49. Y Combinator and biotech: The wave of the future?
  50. "A Fred Sanger would not survive today's world of science."
  51. "Designing drugs without chemicals"
  52. Reproducibility in molecular modeling research
  53. All active kinase states are similar but...
  54. High-throughput method for detecting intramolecular hydrogen bonds (IHBs)
  55. Why the new NIH guidelines for psychiatric drug testing worry me
  56. Cosmological inflation, water in proteins and JFK: The enigma of ignorance
  57. Enthusiasm and promise at the ACS Dallas National Meeting
  58. Pity the postdoc
  59. Hiding hydrogen bonding groups in large druglike molecules
  60. Digital features in the Journal of Medicinal Chemistry
  61. What happens when chemists have nothing better to do on a Wednesday afternoon?
  62. On making mistakes
  63. Free online medicinal chemistry course at Davidson College
  64. Syngenta, atrazine and keeping the science separate from the policy
  65. Atomic origin of the Bohr effect
  66. Strolling in other fields

2013 51

  1. Drugable.com "ranks billions of drug interactions"? Hold your horses.
  2. The future of nuclear energy: Let a thousand flowers bloom
  3. The golden age of computational materials science gives me a disturbing feeling of déjà vu
  4. Enthalpy-entropy compensation and water networks
  5. Barry Werth on the cost of new drugs
  6. Molecular dynamics: I have a bad feeling about this.
  7. Molecular Dynamics: Manna from heaven or spawn of Satan?
  8. A discussion on Big Science, Small Science and the future of all science
  9. Arsenic DNA, chemistry and the problem of differing standards of proof in cross-disciplinary science
  10. Computational chemistry wins 2013 Nobel Prize in Chemistry
  11. Nobel Prize for membrane vesicle trafficking
  12. Phil Baran keeps the dream of classical organic chemists alive
  13. 2013 Nobel Prizes
  14. MIT and chemistry: What gives?
  15. Chemical and Engineering News celebrates 90 years: How chemistry has come a long way
  16. Macrocycle drug review
  17. So you hate GMO's because they are untested. What about feelbetteramine from the health store?
  18. Who's afraid of nuclear waste?: WIPPing transuranics into shape
  19. Fairness or intimidation: How do you handle difficult commenters?
  20. Druggability: An optimistic assessment.
  21. Gordon Conference impressions
  22. What are the top five most memorable chemistry papers that you have read?
  23. What does mercury being liquid at room temperature have to do with Einstein's theory of relativity?
  24. A particularly heinous crime: Neurology professor poisons neurologist wife
  25. Memo to chemists: Move away from the molecule
  26. Where's the chemistry lobby?
  27. Thanksgiving
  28. Good luck to B.R.S.M!
  29. Chemistry, fluid dynamics and an awful radioactive mess
  30. On synthesis, design and chemistry's outstanding philosophical problems
  31. George Whitesides on the responsibility of chemists and the future of chemistry
  32. Splenda and - wait for it - DDT? You've got to be kidding me
  33. Stephen Hawking's advice for twenty-first century grads: Embrace complexity
  34. Some thoughts on the events around Boston
  35. Moore's Law for batteries: No dice
  36. Friday levity: 'Nature' discusses ghosts.
  37. Chemical compounds from mouthwash may target cancer cells
  38. Solomon Snyder on academic publishing: ask for adequate, not exhaustive, documentation
  39. First they came for the bloggers and I didn't speak up because...
  40. ENCODE, Apple Maps and function: Why definitions matter
  41. Uncle Syd's idea for funding new assistant professors
  42. On toxic couches and carcinogens: Chemophobia, deconstructed.
  43. Chemistry Nobel Prizes and second acts
  44. Never a simple staple
  45. #Arseniclife reviews: Missing the forest for the trees
  46. Andrew Grant
  47. Virtual shock
  48. The GPCR Network: A model for open scientific collaboration
  49. Review on N-methylation
  50. The value of long-term vision
  51. Who knew VCs had a sense of humor

2012 78

  1. Chemistry and Biology: Kuhnian or Galisonian?
  2. Nobel Week Dialogue
  3. Why the same can be different: The case of the two enantiomers
  4. Angewandte Chemie retracts hexacyclinol paper. Sort of
  5. Occam, me and a conformational medley
  6. Does modern day college and graduate education in chemistry sacrifice rigor for flexibility?
  7. Who's afraid of Big Bad Thermodynamics?
  8. Live blogging the Northeastern Drug Discovery conference
  9. Book review: Benoit Mandelbrot's "The Fractalist"
  10. How to run a world-class lab
  11. ChemCoach Carnival: What I do
  12. In which the Discovery Institute mocks me and reveals its ignorance...again.
  13. When satire hits home
  14. A chestnut so old, it's started stinking
  15. Woodward, and the importance of being born at the right time
  16. Crystallography, chemistry and Nobel Prizes: Nothing to complain about
  17. GPCRs win 2012 Nobel Prize in Chemistry
  18. Let’s all find out how meth works: Crowdfunding a novel scientific paradigm
  19. Why junk DNA makes perfect evolutionary sense
  20. Fraud, not error, accounts for most scientific retractions
  21. Explaining Woodward to the layman
  22. In praise of Small (and Cheap) science
  23. Are chemistry bloggers journalists? Eat the fruit, don't count the trees
  24. Ivano Bertini
  25. Kinetics in drug discovery: The neglected child?
  26. Biotechnology. Misunderstood.
  27. 2012 Nobel Prizes
  28. Drug discovery 2.0: Rise of the biologics? Not so fast
  29. Latest Scientific American posts
  30. Again, drug design and airplane design are not the same
  31. Protein-ligand crystal structures: WYSI(N)WYG
  32. Gene duplication and molecular promiscuity
  33. The Higgs boson and the future of science
  34. Change is here
  35. Zn(III)? Not so fast
  36. "Arsenic bacteria": Coffin, meet nails
  37. The Uncertainty Principle for climate (and chemical) models
  38. Anticancer drugs form colloidal aggregates and lose activity
  39. P-glycoprotein: The vacuum cleaner that makes Sir James weep
  40. "Arsenic bacteria": If you hadn't nailed 'im to the perch 'e'd be pushing up the daisies
  41. An almost-Nobelist's lesson to his daughter
  42. The protein makes the poison: Dancing fruit flies and terfenadine
  43. Physics's PR problem: Moving beyond string theory and multiple universes
  44. Striking Alzheimer's before it strikes
  45. John LaMattina on the new NIH drug discovery center
  46. A history of metallocenes: Bringing on the hashish
  47. The devil under the hood: To look or not to look?
  48. Nanopore sequencing: The next big thing?
  49. Woodward on how to travel incognito
  50. Using gas-phase conformations to predict membrane permeability of drugs
  51. The anatomy of peer review: Why airing dirty laundry in public is important
  52. Would Ron Breslow's dinosaurs be typing this post?
  53. Modeling magic methyls
  54. A citation against citations
  55. On Freeman Dyson, cadmium estimation and the joy of chemistry
  56. A molecular modeler's view of molecular beauty
  57. On physics envy and drug discovery
  58. On Michael Dewar, Robin Collingwood and models in chemistry
  59. How it came from bit: Review of George Dyson's "Turing's Cathedral"
  60. UNC physics professor held on cocaine smuggling charges
  61. Book review: The Idea Factory: Bell Labs and the Great Age of American Innovation
  62. If you want them to collaborate, you should let them collaborate
  63. The unstoppable Moore hits the immovable Eroom
  64. Gilbert Stork on steaks, synthesis and more
  65. Why it's hard to explain drug discovery to physicists
  66. A new way to look for life on other planets
  67. The right questions about modeling in drug discovery
  68. The man who made it possible
  69. The end of biofuels?
  70. Identifying new drug targets in zebrafish
  71. Roald Hoffmann on the futility of classifying chemists
  72. Book review: Philip Anderson's "More and Different"
  73. The Sheri Sangji accident: The experimental details
  74. Will quantum physics help us cure Alzheimer's disease?
  75. Introverts, extroverts and modern science
  76. Fraud in a glass of wine
  77. What is your favorite deep, elegant or beautiful explanation (in chemistry)?
  78. Molecular modeling: How far can physics take us?

2011 82

  1. Is it too early to ask for automation in lab safety?
  2. Professorial oversight, availability bias and the Sheri Sangji case
  3. A Christmas message from Steve Jobs for our friends in pharma
  4. Unruly beasts in the jungle of molecular modeling
  5. On reproducibility in modeling
  6. Why drug design is like airplane design. And why it isn't.
  7. Truth and beauty in chemistry
  8. The future of computation in drug discovery
  9. Autism studies among the Asian-American diaspora.
  10. A Nobel Prize for "fundamental biology"?
  11. Age is of course a fever chill?: Why even older scientists can make important contributions
  12. Overturning hydrophobic assumptions
  13. Scientific challenges in drug discovery (Part 1): We are still infants
  14. GPCR modeling: The devil hasn't left the details
  15. On being a computational chemist in industry
  16. The future of science: Will models usurp theories?
  17. Chemistry Nobel Prizes redux
  18. A posthumous Nobel Prize
  19. Book review: Robert Laughlin's "Powering the Future"
  20. The flame of life and death: My favorite (insufferable) chemical reaction
  21. Rookie mistakes in molecular modeling: Part 1
  22. In which creationists' understanding of amyloid appears...tangled
  23. 2011 Nobel Prizes
  24. Thoughts on personalized medicine
  25. Are chemists much more secretive and obsessive than physicists?
  26. Why biology (and chemistry) is not physics
  27. No ordinary geniuses
  28. The barrier to amyloid formation is kinetic, not thermodynamic
  29. Why conduct reactions at low temperature?
  30. Who are your favorite technical writers in chemistry?
  31. What would Woodward say?: Giants of chemistry in the year 2011
  32. On chemistry's multiple cultures
  33. What lessons did you learn from your graduate school advisor?
  34. What is chemical intuition?
  35. Lindau 2011: What do you want me to translate now?
  36. The protein folding funnel and its discontents
  37. Lindau 2011: What do scientists do after winning the Nobel Prize?
  38. The fine-tuning problem in protein folding: Is there a protein multiverse?
  39. Lindau 2011: From designing airplanes to designing proteins
  40. Putting the filosophy back into fysiks
  41. Lindau 2011: The beginning
  42. God is not only unsubtle but she is malicious
  43. Why would a molecule become more soluble at low temperature?
  44. Xtreme C-H functionalization: Natural Edition
  45. Links...
  46. The top four publicly misused chemical terms: A layman's primer
  47. One more thing we can learn from Linus Pauling
  48. Dirac, Bernstein, Weinberg and the limits of reductionism
  49. A singular lament
  50. A marvelous fox: William Lipscomb (1919-2011)
  51. Hedgehogs and foxes in chemistry
  52. How (not) to get tenure
  53. The burden of biological organization
  54. How a college student can derive the RNA world hypothesis from scratch
  55. Note on the cultish status of organic synthesis: Part 2
  56. The long grave dug?
  57. Gray and Labinger on chemistry's big problems
  58. What is chemistry's greatest achievement?
  59. Perspective...again
  60. Important or interesting; what is more important?
  61. Book review: Andrew Roberts's "The Storm of War"
  62. Why should chemists study the origin of life?
  63. Slices from the literature
  64. When Iron and Bacteria tragically collide: From the Middle Ages to the University of Chicago
  65. Note on the cultish status of organic synthesis: Part 1
  66. A few of my favorite (chemical) things...
  67. Who are the greatest chemistry teachers?
  68. "The Thexperiment Cafe": Bridging theory and experiment?
  69. Woodward on the difference between mathematics and chemistry
  70. Delivering a few Knox
  71. Chemistry: The difference between important and useful
  72. Is the age of traditional organic synthesis over?
  73. The road not taken: Do you have the courage to let go?
  74. The difference between chemistry and physics: Part 2
  75. The bundle of non-truths that's Deepak Chopra
  76. A government center for drug discovery?
  77. Phosphorus beats arsenic...by a factor of seventeen powers of ten
  78. How can we make the International Year of Chemistry successful?
  79. The "greatest" chemist ever, and the nature of chemistry
  80. Ye olde physicists
  81. What mad pursuit...
  82. Better extraterrestrial communication through chemistry: What do aliens want?

2010 95

  1. Ode to a classic: The Nature of the Chemical Bond
  2. New place, new view, slow reactions and the origins of life
  3. Making speculation official: More on the conservatism of leading science journals
  4. Aliens, arsenic and alternative peer-review: Has science publishing become too conservative?
  5. An eternity of infinities: the power and beauty of mathematics
  6. Medicine! Poison! Arsenic! Life itself!
  7. Probing amyloid, one oligomer at a time
  8. In praise of contradiction
  9. Will-o'-the-wisp around 5 sigma: the hunting of the Higgs
  10. Life (and chemistry) is a box of models
  11. Why are secondary amines the most basic?
  12. A graceful collapse
  13. How about a graphite ring for getting engaged?
  14. A limitless life
  15. Functional selectivity: Nature's Bach concerto
  16. "The most ludicrous system ever devised"
  17. In praise of cheap science
  18. What they found in the virtual screening jungle
  19. New kid on the GPCR block
  20. What is 'elegance' in chemistry?
  21. The Velvet Undergrounds of science
  22. Finally, now everybody can stop complaining
  23. Graphene: Physics or Chemistry?
  24. Graphene!
  25. From the mouths of (test-tube) babes
  26. Why the free market is like quantum mechanics
  27. But Bohr never said anything about Nobel Prizes
  28. Does bond cleavage require or release energy?
  29. 'SAR by C13 NMR'
  30. Drugging the cell's best friend
  31. Fishin' in the membrane
  32. Why modeling GPCRs is (still) hard
  33. The price of teaching
  34. Louisa Gilder and Robert Oppenheimer
  35. The difference between chemistry and physics
  36. My E. coli brother's keeper
  37. Stimulating quasi-erotic excitement through organic structure determination
  38. Assessing computationally designed enzymes
  39. Riding off into the twilight...
  40. Miles to go before...
  41. From bull horns to under the lens of Anton
  42. R B Woodward lives!: ACS Day 2
  43. ACS Day 1
  44. Casually overheard: in the restaurant, in the restroom and down the hall
  45. Woodward-Hoffman-Schmoffman?
  46. Briefly noted
  47. Open-sourcing Alzheimer's diagnosis
  48. Chembark is back!
  49. Briefly noted
  50. Remember
  51. Humans beat computers in predicting protein structures
  52. Shattering the nuclear sword
  53. Curbing the combinatorial catch
  54. Models, laws and the limits of reductionism
  55. The jewel of physics faces the 4% challenge
  56. Computational modeling of GPCRs: What are the challenges?
  57. Lindau 2010: Island Full of Ideas
  58. Parallel worlds, parallel lives
  59. The origin of life cannot escape basic organic chemistry
  60. The aesthete
  61. Conformations of the stevastelins: A reassessment
  62. A shot in the arm for antimalarial drug discovery?
  63. Life anew?
  64. Perturbed by Free Energy Perturbation?
  65. It's truly the entropy that binds us together
  66. Steering library bias toward A2A adenosine receptor ligand discovery
  67. It's (not) the mutation, stupid
  68. You have a Ph.D.?? Who doesn't!
  69. The beta-amyloid hyp(e)othesis; the saga continues
  70. New hominid fossil has 9-year-old discoverer
  71. Will virtual screening ever work?
  72. Distinguishing statistical significance from clinical significance
  73. How useful is cheminformatics in drug discovery?
  74. How pretty is your (im)perfect p?
  75. Chips worth their salt
  76. The details do matter
  77. Remote control of peptide screw sense
  78. Screening probes and probing screens
  79. Middle Ages March
  80. A promising book falls apart
  81. Marshall Nirenberg (1927-2010)
  82. Book review: The Dale Carnegie of Silicon-29 NMR
  83. Intramolecular hydrogen bonds in medicinal chemistry
  84. Quo Vadis, natural science?
  85. An alternative BBC list for the "educated" mind
  86. The writings of John Cassidy
  87. Scaling further GPCR summits
  88. Linkland
  89. Indian village has unusually low rates of Alzheimer's disease
  90. Simulations long enough to...put you to sleep
  91. When radiation misfires...literally
  92. Go, learn some linear algebra
  93. How much chemistry can we wring out of the universe?
  94. A biochemical parody of Bryan Adams
  95. Almost back

2009 112

  1. The price of global warming science is eternal vigilance
  2. The damning global warming emails; when science becomes the casualty
  3. More model perils; parametrize this
  4. California axes science
  5. What did you say the error was??
  6. A new look, with hair combed and shoes brushed
  7. A hermitian operator in self-imposed exile
  8. Constancy of the discodermolide hairpin motif
  9. Warren DeLano
  10. A wrong kind of religion; Freeman Dyson, Superfreakonomics, and global warming
  11. That is verboten
  12. Tautomers need some love
  13. The model zoo
  14. New Book
  15. At the Bryn Mawr eCheminfo Conference
  16. Coyne vs Dawkins
  17. The 2009 Nobel Prize in Chemistry: Ramakrishnan, Steitz and Yonath
  18. Update: Kao, Boyle and Smith
  19. The 2009 Nobel Prize in Physiology or Medicine
  20. Update: Blackburn, Greider, Szostak
  21. The evils of our time
  22. That time of the year
  23. First potential HIV vaccine
  24. The emerging field of network biology
  25. One day left before the singularity
  26. Missile shield to be scrapped
  27. First pentacene, now this
  28. Norman Borlaug (1914-2009)
  29. Can natural sciences be taught without recourse to evolution?
  30. Olivia Judson on "Creation"
  31. Impressionist thoughts on Rosetta
  32. Can you at least get the solvation energy right?
  33. Books on evolution
  34. An unusual epoxidation of amides
  35. An industrial tour de force laid bare
  36. Hans Bethe; his life, work and times
  37. A small molecule probe discriminating between Aß amyloid oligomers and fibrils
  38. An outstanding one stop shop for drug discovery and development
  39. A journey with the good Lord
  40. The return of the biochemists, but let's not forget selectivity
  41. Water wires and hydrophobics
  42. The same and not the same: more aggregates in HTS
  43. Solid strands of knowledge
  44. Enabling an antibody to jump the species barrier
  45. Can a religious person head the National Institutes of Health?
  46. The leap forward
  47. Just when I was going to order the t-shirt...
  48. The importance of being patient
  49. Lindau: The teachings of the savants
  50. Lindau: Who is the joke going to be on?
  51. Lindau: From fullerenes to global education
  52. Lindau: The way dinner should be
  53. Lindau: the glowing joy of discovery
  54. Wine, wisdom and wish-fulfillment at Lindau
  55. Blogging from ground zero: day zero
  56. "The partisans have ampicillin". Really?
  57. So what exactly are force fields good for?
  58. The anti-question, or when bias can be a good thing
  59. Overmedicated overachievers
  60. Atypically typical: The single vs multiple compound hypothesis in schizophrenia
  61. Presence of absence is not absence of presence
  62. For the love of science
  63. State of the Garden
  64. The 2009 Lindau Nobel Laureates Meeting
  65. And you wonder why atheists bristle when the religious call them 'intolerant'
  66. Drug Discovery, Models and Computers: A (necessarily incomplete) Personal Take
  67. Demolishing the 'vacuous' argument for the RRW
  68. FDA does, and should, stick to only science
  69. Timeless Classics
  70. The Pope of Cosmology 'very ill'
  71. Assessing the known and unknown unknowns: WYSI(N)WYG
  72. Reading C P Snow and The Two Cultures
  73. The rest is all noise: errors in R values, and the greatness of Carl Friedrich Gauss reiterated
  74. Much ado about protein dynamics
  75. New ligands for everyone's favorite protein
  76. Post-docking as a post-doc, and some fragment docking
  77. It's been a good ride...
  78. An honest heretic
  79. Meta-substitution: challenging a classic textbook paradigm
  80. Czechs halt missile shield progress
  81. So salt bridges are not stable in water? Shocking
  82. A first-class mental workout
  83. The real costs of generics
  84. Why nature chose phosphates
  85. Hexacyclinol: Case Closed
  86. Met/VEGFR/FGFR inhibitors by VS
  87. Year of Charles
  88. Another entertaining exchange
  89. Graham Farmelo's long-awaited Paul Dirac biography
  90. Dear New York Times
  91. Samoquasine is perlolidine after all
  92. That about says it
  93. Blogging will be slow
  94. A Drug Design Class Act: ∆S or ∆H?
  95. Some slices from the literature
  96. Author's delight
  97. PBS film on Oppenheimer
  98. Fundamentals of Asymmetric Catalysis
  99. A beautiful, informal and comprehensive account of quantum history
  100. Strain Energies in Ligand Binding: Round Two- Fight!
  101. This is how science should be taught
  102. The wrath of lithium
  103. Welcome back...
  104. An Excellent Primer
  105. Obama's threat reduction priorities
  106. Kinase substrates detected by dansylation
  107. Targeting early AD oligomers with a simple dipeptide
  108. The Black Swans of Chemistry Models
  109. Heavy Me
  110. The Ghost of Alfred Kinsey?
  111. Gupta for Surgeon General?
  112. Boulevard of Broken Dreams

2008 77

  1. The H-Bomb Fuchs?
  2. Deconstructing Little Boy and Fat Man
  3. Buying Used Books on Amazon
  4. ∆G, ∆G†† and All That: Implications for NMR
  5. Does a protein-bound ligand exist in only one conformation?
  6. Sleep well through chemistry...forever
  7. Article on NAMFIS in IIT-D magazine
  8. Help
  9. Please, save science from the "holists"
  10. Whose fault is it, again?
  11. Selective vs Multitargeted Kinase Inhibitors: Still in the Stone Age
  12. History
  13. Save Science on Tuesday
  14. Break
  15. The Unbearable Heat Capacity of Being
  16. Off the list
  17. 2008 Medicine Nobel: Montagnier finally wins
  18. Emory in a little, Nemeroff in big, trouble
  19. Fizz or Fizzle: The 2008 Nobels
  20. What's an Iodide doing stabilizing a helix?
  21. Please, don't stand in the way of this man
  22. Thinking about Alzheimer's Disease as Historians
  23. Water-Inclusive Docking with Remarkable Approximations
  24. Aldrichimica Acta Woodward Memoirs
  25. Thanks for all the fish
  26. Gernot Frenking is not happy...not at all
  27. Vytorin: New Problems for a New Era
  28. Tipping Point
  29. The End of Industrial Productivity?
  30. Water and Amyloid Self-Assembly
  31. I exist
  32. I am full of piety
  33. Why is body temperature 36 degrees celsius?
  34. Rip
  35. Aß Dimers- The Long-Sought Minimal Culprit in Alzheimer's Disease?
  36. ADMET@TheSpeedOfThought
  37. Multiconformational MMGBSA Rescoring; Advancing On Mount Free Energy
  38. Glad to be away from home
  39. Portland, Powell's
  40. Myths about disrupting protein-protein interactions with small molecules
  41. Elegant switches in an E. Coli ion channel
  42. Computational modeling of GPCRs: not too bad
  43. Hexacyclinol as a test case: ab initio C13 chemical shift prediction
  44. It's Clay Time: The Origins of "Silicon-Based" Life
  45. Force field dependence of conformational energies
  46. Magic without Magic: John Archibald Wheeler (1911-2008)
  47. Large-scale effects of a nuclear war between India and Pakistan
  48. Profile of a fiend
  49. Picture says more than a thousand words
  50. Quote of the day...no, of the year
  51. Datasets in Virtual Screening: starting off on the right foot
  52. Expelled! No nuance allowed
  53. On anonymous blogging
  54. The Gate
  55. Southwestern interlude
  56. SAMPLing out in the desert
  57. A rash of molecular personalities
  58. Space: The Violent Frontier?
  59. "The name's Inhibitor. Kinase Inhibitor"
  60. Jim Watson, 'seed'y guy
  61. Corn on the sob
  62. Invasion
  63. A relatively rare example of docking-based virtual screening
  64. 70% of Americans may find nano "morally unacceptable"
  65. A fair effort
  66. Who should be the next President's Science Advisor?
  67. Fraud galore: another plagiarisophilic chemist
  68. Top 5 reasons why intelligent liberals don’t like nuclear energy
  69. Score for the British
  70. The negative IQ people at the State Department
  71. Richard Rhodes@Google
  72. Woodward, rest in peace
  73. Life's Matrix
  74. Judah Folkman
  75. Another much-feared chemical agent bites...tubulin
  76. Can we predict solvation energies from first principles yet?
  77. On vacation

2007 133

  1. A novel paradigm in understanding antibiotic action?
  2. Another need for nuclear energy
  3. Semen gives us a Christmas gift
  4. Amazing pumping
  5. Time to take MRSA seriously
  6. The impressive chemistry knowledge of talk-show hosts
  7. You have my ears mate
  8. Bacteria win
  9. The price of scientific ignorance will be liberty itself
  10. The OpenEye SAMPL challenge
  11. How many of you folks are sniffing toluene right now?
  12. Two pioneers pass into history
  13. Enzymes as drug targets
  14. Octagenarian worms on Prozac
  15. Never a dull pharmacophore
  16. Man-sized scorpion's claw found
  17. Skin cells to stem cells
  18. Mountains of malicious mutations
  19. Ethanol: saviour of the unfortunate...and the stupid
  20. Increasing the bioavailability of Curcumin
  21. Give the kid S-15535, said Dad
  22. A simple substitution to possibly avoid phenol elimination
  23. Paraquat, paraquat...
  24. Why I have scant patience with postmodernists
  25. GHB in Aqua Dots
  26. As bad as it gets: a debate with two surprisingly creationist gentlemen
  27. You've lost that gut feeling
  28. What doth a methylene?
  29. The Traffic Light
  30. Nuclear terrorism's unheeded assumptions?
  31. A chat with Nobel laureate Peter Agre
  32. "Duh" newspiece of the day
  33. Unclear? No, it's nuclear
  34. The only existing O-H...F-C bond...not
  35. Please don't kill the message
  36. Who is the fairer one; H or X?
  37. Don't squelch eccentricity
  38. "Don't silence the scientists"
  39. Kornberg goes nano
  40. When scientists get old and boring...
  41. Paradise regained?
  42. Interview with Brian Shoichet: aggregation-induced inhibition
  43. Ertl gets the Nobel, but Somorjai?
  44. 2007 Chemistry Prize: last minute revision
  45. 2007 Physics
  46. Turning a false-positive into an active
  47. 2007 Medicine Nobel
  48. Miles to go before...
  49. Fluorine in pharmaceuticals
  50. 2007 Nobel Prizes
  51. Lomborg on Maher
  52. Three lessons
  53. The Open Society
  54. Queen and country and all that
  55. Trad med and all that
  56. Plagiarism Inc.
  57. The scariest graph I have seen in a while
  58. Freeman Dyson (1923-): Vignettes in science- 1
  59. Right mind at right place at right time
  60. The making of Darunavir
  61. Water-inhibitor synergy in CDKs
  62. H for?...
  63. Who was smarter?
  64. Path-y-ological science: Homeopathy and the memory of water
  65. Another joy
  66. As addicted as can be
  67. A coterie of pyridines
  68. Carbene 'decarbenized'
  69. Numbers worth knowing
  70. Daniel Koshland
  71. Weird scis-strans observation
  72. The BI guys should have used Glide XP Dock
  73. BI p38 inhibitors: breaking from the urea
  74. Favourite author among 2006 medalists
  75. Is there cause for optimism?
  76. Book review: Pharmacology for Chemists
  77. Killing polyavians with a unistone: designing promiscuous drugs
  78. "I run from reality"
  79. Slippery questions
  80. CARDD: Relatively simple this time
  81. Can water stand the heat of a hydrophobic carbon nanotube?
  82. How much water does it hold?
  83. Amidine-aminoisoquinoline substitution
  84. The strange case of entropy-enthalpy compensation
  85. Culprit?
  86. I am not the only one! Getting past the original GBSA
  87. Charity begins in the university
  88. Boston ahoy. Pharma ahoy.
  89. SBDD Boston 1
  90. Pretty basic stuff
  91. How to garnish a kinase sales pitch
  92. CHI SBD
  93. AD, metals, and evolution
  94. The beastly behemoth
  95. Tortoise defends its territory from cat
  96. MD? Check...at least in this case
  97. The mighty Maito
  98. Sad and totally unexpected...
  99. The last humane act?
  100. Disgusting damn popups
  101. How do you choose a good crystal structure for docking?
  102. Schrodinger's equation
  103. Decide how you want to die...
  104. Analogies between analogies: The character of Stan Ulam
  105. How not to design a fly killer
  106. Trans-biotin?
  107. New tagline for SBDD
  108. R.I.P Frank
  109. Questions for the kinase biologists
  110. Some clerihews
  111. Why I don't want to get into genome sequencing
  112. The first miracle drug
  113. Smells from the sea
  114. The Emperor of Scent
  115. The cyanuric acid-melamine doggie
  116. The mystical Sir Isaac
  117. Worst and best
  118. Inside the "graduate kitchen"...and what I found there
  119. Book review- The Weak Hydrogen Bond: In Structural Chemistry and Biology
  120. Question for NMR/Internet enthusiasts
  121. I wanna smell some H2Po
  122. Praise the warts please
  123. The Hallmarks of Cancer
  124. Bathroom tiles and acid trips
  125. DMSO to SAHA: Questions of toxicity
  126. Least favourite NMR solvent, but a swell liquid nonetheless
  127. The passing of Gossypium extraordinarium
  128. All transition metals exist only in +1 state (or a close approximation thereof)
  129. Nature adores a vacuum?
  130. CETP resolved
  131. The Looming Book Tower
  132. Good and memorable speakers...
  133. On Vacation

2006 59

  1. Perfume for the gods
  2. pKa bamboozle
  3. Look ma, pet dinosaur
  4. Strontium ralenate
  5. Clerical Chemistry
  6. Eternal unanswered riddles
  7. Of course I can google it, but...
  8. Features of selective kinase inhibitors
  9. Discodermolide unraveled?
  10. Protein-protein interactions and academic bounties
  11. Low is still better
  12. Fishy no more
  13. Smith's Interestingolide is wrong
  14. It's the simple things that...
  15. Beyond the rhetoric
  16. The same and the not same
  17. Bizarre halloween paper of the year
  18. Cholesterol in plants fun fact
  19. Hiatus
  20. 'But is it chemistry?' hits Nature
  21. Wrong data makes me happy
  22. In the beginning...
  23. The Trouble With Everything
  24. Chartelline and copper catalyzed decarboxylation
  25. Schrodinger Webinars 2006. And the importance of being polarized
  26. Whither chemistry?
  27. Chemistry Nobel for Biologist
  28. Nitrone-cyclopropane cycloaddition
  29. Corwin Hansch
  30. Solvent assisted olefin epoxidation: fluorine emerges a winner
  31. The Penicillin before Penicillin
  32. Dock dock, who is there?
  33. Obviously Elusive
  34. Panek's Leucascandrolide A
  35. Medals and Champagne Fizz
  36. More nitrile oxide histrionics
  37. Glimpse into history
  38. WHO is DDT
  39. Cation-pies in squalene synthases
  40. Stereochemistry by natural selection
  41. Vinylcyclobutane-cyclohexene reaction in natural products
  42. Modern Physical Organic Chemistry
  43. College Chemistry Carbocation Cinch
  44. New Look
  45. Killing the Hydra
  46. The Discovery of Global Warming
  47. Duplicate duplicate...And the sad case of hexacyclinol
  48. Once-a-day cocktail for HIV
  49. Cyanide poisoning failed, student died
  50. The reach of the penguins
  51. Fat fatter fattest
  52. The Ghosts of Molecules Past?
  53. Engineering evolving by natural selection
  54. Pretty much says it
  55. Sam
  56. It was little suprising for me to see
  57. Did you say research?
  58. Science in a straitjacket
  59. The end of determinism...

2005 19

  1. What pity in eyring walter and
  2. HANS ALBRECHT BETHE: PHYSICIST EXTRAORDINAIRE (1906-2005)
  3. GP120 UNDRESSED...
  4. NEW BIOGRAPHY SOON TO COME
  5. 'PHODNI' FOR ALZHEIMER'S...
  6. GOD, SCIENCE AND THE COMMON GOOD...
  7. Modern art?? No! Drugs!!
  8. No Gain for Fenn
  9. THE PULPIT AND THE LAB
  10. THE DEVIL'S ELEMENT
  11. ANNOYING, IF NOT STUPID...LEAVE NATURE ALONE!
  12. 1, 2, 3...ENOUGH FOR ME!
  13. N-E-W-S
  14. ROBERT OPPENHEIMER: PORTRAIT OF AN ENIGMA...
  15. ALEXANDER FLEMING-THE MAN AND THE MYTH: BY GWYN MACFARLANE
  16. PAUL DIRAC...SILENCE IS GOLDEN
  17. SPIDEY 2, OTTO OCTAVIUS AND EDWARD TELLER...
  18. Article transfer: History and Philosophy of Science
  19. YOU DRIVE ME CRAZY BABY...

2004 3

  1. Stem cells and the greater good...
  2. History...
  3. In the beginning...